A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies

Huntington's disease (HD) is a monogenic, progressive, neurodegenerative disorder with currently no available treatment. The Libechov transgenic minipig model for HD (TgHD) displays neuroanatomical similarities to humans and exhibits slow disease progression, and is therefore more powerful than...

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Bibliografiske detaljer
Udgivet i:Dis Model Mech
Main Authors: Askeland, Georgina, Rodinova, Marie, Štufková, Hana, Dosoudilova, Zaneta, Baxa, Monika, Smatlikova, Petra, Bohuslavova, Bozena, Klempir, Jiri, Nguyen, The Duong, Kuśnierczyk, Anna, Bjørås, Magnar, Klungland, Arne, Hansikova, Hana, Ellederova, Zdenka, Eide, Lars
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215428/
https://ncbi.nlm.nih.gov/pubmed/30254085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.035949
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