Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington’s disease patients

Huntington’s disease (HD) is a progressive neurodegenerative disorder primarily affecting the basal ganglia and is caused by expanded CAG repeats in the huntingtin gene. Except for CAG sizing, mitochondrial and nuclear DNA (mtDNA and nDNA) parameters have not yet proven to be representative biomarke...

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Publicado en:Sci Rep
Main Authors: Askeland, Georgina, Dosoudilova, Zaneta, Rodinova, Marie, Klempir, Jiri, Liskova, Irena, Kuśnierczyk, Anna, Bjørås, Magnar, Nesse, Gaute, Klungland, Arne, Hansikova, Hana, Eide, Lars
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6026140/
https://ncbi.nlm.nih.gov/pubmed/29959348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27985-y
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