Deterioration of mitochondrial bioenergetics and ultrastructure impairment in skeletal muscle of a transgenic minipig model in the early stages of Huntington's disease

Skeletal muscle wasting and atrophy is one of the more severe clinical impairments resulting from the progression of Huntington's disease (HD). Mitochondrial dysfunction may play a significant role in the etiology of HD, but the specific condition of mitochondria in muscle has not been widely s...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Rodinova, Marie, Krizova, Jana, Stufkova, Hana, Bohuslavova, Bozena, Askeland, Georgina, Dosoudilova, Zaneta, Juhas, Stefan, Juhasova, Jana, Ellederova, Zdenka, Zeman, Jiri, Eide, Lars, Motlik, Jan, Hansikova, Hana
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6679385/
https://ncbi.nlm.nih.gov/pubmed/31278192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.038737
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