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Urea Memory: Transient Cell Exposure to Urea Causes Persistent Mitochondrial ROS Production and Endothelial Dysfunction

Urea at post-dialysis levels induces increased ROS in a number of cell types. The aim of this study was to determine whether urea-induced production of ROS remains elevated after urea is no longer present, and, if it does, to characterize its origin and effects. Human arterial endothelial cells were...

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Detalhes bibliográficos
Publicado no:Toxins (Basel)
Main Authors: d’Apolito, Maria, Colia, Anna Laura, Manca, Enrica, Pettoello-Mantovani, Massimo, Sacco, Michele, Maffione, Angela Bruna, Brownlee, Michael, Giardino, Ida
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215169/
https://ncbi.nlm.nih.gov/pubmed/30314315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins10100410
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