Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis

Although additional sex combs-like 1 (ASXL1) has been extensively described in hematologic malignancies, little is known about the molecular role of ASXL1 in organ development. Here, we show that Asxl1 ablation in mice results in postnatal lethality due to cyanosis, a respiratory failure. This lung...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Moon, Seungtae, Im, Sun-Kyoung, Kim, Nackhyoung, Youn, Hyesook, Park, Ui-Hyun, Kim, Joo-Yeon, Kim, A.-Reum, An, So-Jung, Kim, Ji-Hoon, Sun, Woong, Hwang, Jin-Taek, Kim, Eun-Joo, Um, Soo-Jong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215009/
https://ncbi.nlm.nih.gov/pubmed/30389914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1171-z
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