Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis

Although additional sex combs-like 1 (ASXL1) has been extensively described in hematologic malignancies, little is known about the molecular role of ASXL1 in organ development. Here, we show that Asxl1 ablation in mice results in postnatal lethality due to cyanosis, a respiratory failure. This lung...

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Publicat a:Cell Death Dis
Autors principals: Moon, Seungtae, Im, Sun-Kyoung, Kim, Nackhyoung, Youn, Hyesook, Park, Ui-Hyun, Kim, Joo-Yeon, Kim, A.-Reum, An, So-Jung, Kim, Ji-Hoon, Sun, Woong, Hwang, Jin-Taek, Kim, Eun-Joo, Um, Soo-Jong
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6215009/
https://ncbi.nlm.nih.gov/pubmed/30389914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-1171-z
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