Potassium usnate, a water-soluble usnic acid salt, shows enhanced bioavailability and inhibits invasion and metastasis in colorectal cancer

Usnic acid (UA), a lichen secondary substance, has considerable anticancer activity in vitro, whereas its effect in vivo is limited. Here, potassium usnate (KU) was prepared by the salinization of UA to enhance its water solubility. KU showed increased bioavailability compared with UA in the tumor,...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Yang, Yi, Bae, Woo Kyun, Lee, Ji-Yoon, Choi, Yong Jae, Lee, Kyung Hwa, Park, Myong-Suk, Yu, Young Hyun, Park, So-Yeon, Zhou, Rui, Taş, İsa, Gamage, Chathurika, Paik, Man-Jeong, Lee, Jae Hyuk, Chung, Ik Joo, Kim, Kyung Keun, Hur, Jae-Seoun, Kim, Sang Kyum, Ha, Hyung-Ho, Kim, Hangun
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214985/
https://ncbi.nlm.nih.gov/pubmed/30390003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34709-9
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