Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

The availability of multiple datasets comprising genome-scale RNAi viability screens in hundreds of diverse cancer cell lines presents new opportunities for understanding cancer vulnerabilities. Integrated analyses of these data to assess differential dependency across genes and cell lines are chall...

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Vydáno v:Nat Commun
Hlavní autoři: McFarland, James M., Ho, Zandra V., Kugener, Guillaume, Dempster, Joshua M., Montgomery, Phillip G., Bryan, Jordan G., Krill-Burger, John M., Green, Thomas M., Vazquez, Francisca, Boehm, Jesse S., Golub, Todd R., Hahn, William C., Root, David E., Tsherniak, Aviad
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214982/
https://ncbi.nlm.nih.gov/pubmed/30389920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06916-5
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