A First-Generation Pediatric Cancer Dependency Map

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known for remarkably few mutations which often encode proteins considered challe...

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Vydáno v:Nat Genet
Hlavní autoři: Dharia, Neekesh V., Kugener, Guillaume, Guenther, Lillian M., Malone, Clare F., Durbin, Adam D., Hong, Andrew L., Howard, Thomas P., Bandopadhayay, Pratiti, Wechsler, Caroline S., Fung, Iris, Warren, Allison C., Dempster, Joshua M., Krill-Burger, John M., Paolella, Brenton R., Moh, Phoebe, Jha, Nishant, Tang, Andrew, Montgomery, Philip, Boehm, Jesse S., Hahn, William C., Roberts, Charles W. M., McFarland, James M., Tsherniak, Aviad, Golub, Todd R., Vazquez, Francisca, Stegmaier, Kimberly
Médium: Artigo
Jazyk:Inglês
Vydáno: 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8049517/
https://ncbi.nlm.nih.gov/pubmed/33753930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-021-00819-w
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