Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies

Activation of platelet-derived growth factor receptor alpha (PDGFRA) by genomic aberrations contributes to tumor progression in several tumor types. In this study, we characterize 16 novel PDGFRA mutations identified from different tumor types and identify three previously uncharacterized activating...

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Pubblicato in:Nat Commun
Autori principali: Ip, Carman K. M., Ng, Patrick K. S., Jeong, Kang Jin, Shao, S. H., Ju, Zhenlin, Leonard, P. G., Hua, Xu, Vellano, Christopher P., Woessner, Richard, Sahni, Nidhi, Scott, Kenneth L., Mills, Gordon B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214970/
https://ncbi.nlm.nih.gov/pubmed/30389923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06949-w
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