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Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ‐Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal

BACKGROUND: The ventral tegmental area (VTA) is important for alcohol‐related reward and reinforcement. Mouse VTA neurons are hyposensitive to γ‐aminobutyric acid (GABA) during ethanol (EtOH) withdrawal, and GABA responsiveness is normalized by in vitro treatment with histone deacetylase inhibitors...

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Bibliographische Detailangaben
Veröffentlicht in:Alcohol Clin Exp Res
Hauptverfasser: You, Chang, Vandegrift, Bertha J., Zhang, Huaibo, Lasek, Amy W., Pandey, Subhash C., Brodie, Mark S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214766/
https://ncbi.nlm.nih.gov/pubmed/30103280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13870
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