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Histone Deacetylase Inhibitor Suberanilohydroxamic Acid Treatment Reverses Hyposensitivity to γ‐Aminobutyric Acid in the Ventral Tegmental Area During Ethanol Withdrawal

BACKGROUND: The ventral tegmental area (VTA) is important for alcohol‐related reward and reinforcement. Mouse VTA neurons are hyposensitive to γ‐aminobutyric acid (GABA) during ethanol (EtOH) withdrawal, and GABA responsiveness is normalized by in vitro treatment with histone deacetylase inhibitors...

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Bibliografiske detaljer
Udgivet i:Alcohol Clin Exp Res
Main Authors: You, Chang, Vandegrift, Bertha J., Zhang, Huaibo, Lasek, Amy W., Pandey, Subhash C., Brodie, Mark S.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214766/
https://ncbi.nlm.nih.gov/pubmed/30103280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.13870
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