Cholinergic Signaling via Muscarinic Receptors Directly and Indirectly Suppresses Pancreatic Tumorigenesis and Cancer Stemness

In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of pancreatic cancer (PDAC) has not been defined. Here, we found that subdiaphragmatic vagotomy in LSL-Kras...

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Gepubliceerd in:Cancer Discov
Hoofdauteurs: Renz, Bernhard W., Tanaka, Takayuki, Sunagawa, Masaki, Takahashi, Ryota, Jiang, Zhengyu, Macchini, Marina, Dantes, Zahra, Valenti, Giovanni, White, Ruth A., Middelhoff, Moritz A., Ilmer, Matthias, Oberstein, Paul E., Angele, Martin K., Deng, Huan, Hayakawa, Yoku, Westphalen, C. Benedikt, Werner, Jens, Remotti, Helen, Reichert, Maximilian, Tailor, Yagnesh H., Nagar, Karan, Friedman, Richard A., Iuga, Alina C., Olive, Kenneth P, Wang, Timothy C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214763/
https://ncbi.nlm.nih.gov/pubmed/30185628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0046
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