Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action

Recent efforts by both academic and pharmaceutical researchers have focused on the HIV-1 capsid (CA) protein as a new therapeutic target. An interprotomer pocket within the hexamer configuration of the CA, which is also a binding site for key host dependency factors, is the target of the most widely...

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Veröffentlicht in:J Drug Des Res
Hauptverfasser: Xu, Jimmy P., Francis, Ashwanth C., Meuser, Megan E., Mankowski, Marie, Ptak, Roger G., Rashad, Adel A., Melikyan, Gregory B., Cocklin, Simon
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214487/
https://ncbi.nlm.nih.gov/pubmed/30393786
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