ZFX mediates non-canonical oncogenic functions of the androgen receptor splice variant 7 (AR-V7) in castrate-resistant prostate cancer

Androgen receptor splice variant 7 (AR-V7) is crucial for prostate cancer progression and therapeutic resistance. We show that, independent of ligand, AR-V7 binds both androgen-responsive elements (ARE) and non-canonical sites distinct from full-length AR (AR-FL) targets. Consequently, AR-V7 not onl...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Cai, Ling, Tsai, Yi-Hsuan, Wang, Ping, Wang, Jun, Li, Dongxu, Fan, Huitao, Zhao, Yilin, Bareja, Rohan, Lu, Rui, Wilson, Elizabeth M., Sboner, Andrea, Whang, Young E., Zheng, Deyou, Parker, Joel S., Earp, H. Shelton, Wang, Gang Greg
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214474/
https://ncbi.nlm.nih.gov/pubmed/30270106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.029
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