Proprotein convertase inhibition promotes ciliated cell differentiation – a potential mechanism for the inhibition of Notch1 signalling by decanoyl‐RVKR‐chloromethylketone

Chronic repetitive rounds of injury and repair in the airway lead to airway remodelling, including ciliated cell loss and mucous cell hyperplasia. Airway remodelling is mediated by many growth and differentiation factors including Notch1, which are proteolytically processed by proprotein convertases...

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Detalhes bibliográficos
Publicado no:J Tissue Eng Regen Med
Main Authors: Lee, Sang‐Nam, Choi, In‐Suk, Kim, Hyun Jun, Yang, Eun Jin, Min, Hyun Jin, Yoon, Joo‐Heon
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214225/
https://ncbi.nlm.nih.gov/pubmed/27878968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/term.2240
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