Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability. Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase, are associated with increased type 2 diabetes risk. L...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Cosentino, Cristina, Toivonen, Sanna, Diaz Villamil, Esteban, Atta, Mohamed, Ravanat, Jean-Luc, Demine, Stéphane, Schiavo, Andrea Alex, Pachera, Nathalie, Deglasse, Jean-Philippe, Jonas, Jean-Christophe, Balboa, Diego, Otonkoski, Timo, Pearson, Ewan R, Marchetti, Piero, Eizirik, Décio L, Cnop, Miriam, Igoillo-Esteve, Mariana
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212784/
https://ncbi.nlm.nih.gov/pubmed/30247717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky839
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