Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

The immunoreceptor tyrosine-based inhibitory motif (ITIM)–containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of ITIM and immunoreceptor tyrosine-based switch motif (ITSM) within the cytop...

詳細記述

保存先:
書誌詳細
出版年:Blood
主要な著者: Geer, Mitchell J., van Geffen, Johanna P., Gopalasingam, Piraveen, Vögtle, Timo, Smith, Christopher W., Heising, Silke, Kuijpers, Marijke J. E., Tullemans, Bibian M. E., Jarvis, Gavin E., Eble, Johannes A., Jeeves, Mark, Overduin, Michael, Heemskerk, Johan W. M., Mazharian, Alexandra, Senis, Yotis A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2018
主題:
Platelets and Thrombopoiesis
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212653/
https://ncbi.nlm.nih.gov/pubmed/29891536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-802975
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