Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis

The immunoreceptor tyrosine-based inhibitory motif (ITIM)–containing receptor G6b-B has emerged as a key regulator of platelet homeostasis. However, it remains unclear how it mediates its effects. Tyrosine phosphorylation of ITIM and immunoreceptor tyrosine-based switch motif (ITSM) within the cytop...

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Dades bibliogràfiques
Publicat a:Blood
Autors principals: Geer, Mitchell J., van Geffen, Johanna P., Gopalasingam, Piraveen, Vögtle, Timo, Smith, Christopher W., Heising, Silke, Kuijpers, Marijke J. E., Tullemans, Bibian M. E., Jarvis, Gavin E., Eble, Johannes A., Jeeves, Mark, Overduin, Michael, Heemskerk, Johan W. M., Mazharian, Alexandra, Senis, Yotis A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2018
Matèries:
Platelets and Thrombopoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212653/
https://ncbi.nlm.nih.gov/pubmed/29891536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-10-802975
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