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Immunoproteasome Inhibition Impairs T and B Cell Activation by Restraining ERK Signaling and Proteostasis

Immunoproteasome (IP) inhibition holds potential as a novel treatment option for various immune-mediated pathologies. The IP inhibitor ONX 0914 reduced T cell cytokine secretion and Th17 polarization and showed pre-clinical efficacy in a range of autoimmune disorders, transplant-allograft rejection,...

詳細記述

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書誌詳細
出版年:Front Immunol
主要な著者: Schmidt, Christian, Berger, Thilo, Groettrup, Marcus, Basler, Michael
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212513/
https://ncbi.nlm.nih.gov/pubmed/30416500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02386
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