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The allosteric activation of cGAS underpins its dynamic signaling landscape
Cyclic G/AMP synthase (cGAS) initiates type-1 interferon responses against cytosolic double-stranded (ds)DNA, which range from antiviral gene expression to apoptosis. The mechanism by which cGAS shapes this diverse signaling landscape remains poorly defined. We find that substrate-binding and dsDNA...
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| Vydáno v: | eLife |
|---|---|
| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
eLife Sciences Publications, Ltd
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6211831/ https://ncbi.nlm.nih.gov/pubmed/30295605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39984 |
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