Role of Thrombospondin-1 in Mechanotransduction and Development of Thoracic Aortic Aneurysm in Mouse and Humans

RATIONALE: Abnormal mechanosensing of smooth muscle cells (SMCs) resulting from the defective elastin-contractile units has been suggested to drive the formation of thoracic aortic aneurysms (TAAs); however, the precise molecular mechanism has not been elucidated. OBJECTIVE: The aim of this study wa...

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Publicado en:Circ Res
Main Authors: Yamashiro, Yoshito, Thang, Bui Quoc, Shin, Seung Jae, Lino, Caroline Antunes, Nakamura, Tomoyuki, Kim, Jungsil, Sugiyama, Kaori, Tokunaga, Chiho, Sakamoto, Hiroaki, Osaka, Motoo, Davis, Elaine C., Wagenseil, Jessica E., Hiramatsu, Yuji, Yanagisawa, Hiromi
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211815/
https://ncbi.nlm.nih.gov/pubmed/30355232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.118.313105
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