Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling

The extracellular matrix (ECM) initiates mechanical cues that activate intracellular signaling through matrix–cell interactions. In blood vessels, additional mechanical cues derived from the pulsatile blood flow and pressure play a pivotal role in homeostasis and disease development. Currently, the...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yamashiro, Yoshito, Thang, Bui Quoc, Ramirez, Karina, Shin, Seung Jae, Kohata, Tomohiro, Ohata, Shigeaki, Nguyen, Tram Anh Vu, Ohtsuki, Sumio, Nagayama, Kazuaki, Yanagisawa, Hiromi
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7211957/
https://ncbi.nlm.nih.gov/pubmed/32321834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1919702117
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