Structure-based mechanism of action of a viral poly(ADP-ribose) polymerase 1-interacting protein facilitating virus replication

Poly(ADP-ribose) polymerase 1 (PARP-1), an enzyme that modifies nuclear proteins by poly(ADP-ribosyl)ation, regulates various cellular activities and restricts the lytic replication of oncogenic gammaherpesviruses by inhibiting the function of replication and transcription activator (RTA), a key swi...

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Bibliografiske detaljer
Udgivet i:IUCrJ
Main Authors: Chung, Woo-Chang, Kim, Junsoo, Kim, Byung Chul, Kang, Hye-Ri, Son, JongHyeon, Ki, Hosam, Hwang, Kwang Yeon, Song, Moon Jung
Format: Artigo
Sprog:Inglês
Udgivet: International Union of Crystallography 2018
Fag:
Research Papers
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211522/
https://ncbi.nlm.nih.gov/pubmed/30443370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252518013854
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