NSD1 Inactivation and SETD2 Mutation Drive a Convergence toward Loss of Function of H3K36 Writers in Clear Cell Renal Cell Carcinomas

Extensive dysregulation of chromatin-modifying genes in dear cell renal cell carcinoma (ccRCC) has been uncovered through next-generation sequencing. However, a scientific understanding of the cross-talk between epigenetic and genomic aberrations remains limited. Here we identify three ccRCC epigene...

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Détails bibliographiques
Publié dans:Cancer Res
Auteurs principaux: Su, Xiaoping, Zhang, Jianping, Mouawad, Roger, Compérat, Eva, Rouprêt, Morgan, Allanic, Frederick, Parra, Jérôme, Bitker, Marc-Olivier, Thompson, Erika J., Gowrishankar, Banumathy, Houldsworth, Jane, Weinstein, John N., Tost, Jorg, Broom, Bradley M., Khayat, David, Spano, Jean-Philippe, Tannir, Nizar M., Malouf, Gabriel G.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211291/
https://ncbi.nlm.nih.gov/pubmed/28754676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0143
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