The significance of enzyme and transporter polymorphisms for imatinib plasma levels and achieving an optimal response in chronic myeloid leukemia patients

INTRODUCTION: Imatinib mesylate is the drug of choice for patients with chronic myeloid leukemia (CML). Imatinib pharmacokinetics is affected by a number of transport proteins and enzymes. MATERIAL AND METHODS: In the present study we evaluated the association of eight polymorphisms in the seven gen...

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Detalhes bibliográficos
Publicado no:Arch Med Sci
Main Authors: Belohlavkova, Petra, Vrbacky, Filip, Voglova, Jaroslava, Racil, Zdenek, Zackova, Daniela, Hrochova, Katerina, Malakova, Jana, Mayer, Jiri, Zak, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: Termedia Publishing House 2018
Assuntos:
Clinical Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209720/
https://ncbi.nlm.nih.gov/pubmed/30393497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5114/aoms.2018.73538
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