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Neuraminidase Mediated Desialylation Augments AAV9 Mediated Gene Expression in Skeletal Muscle
BACKGROUND: Following systemic delivery, AAV9-mediated gene expression is significantly increased in ischemic versus non-ischemic muscle, suggesting AAV9 as an attractive vector for treating peripheral arterial disease (PAD). Potential mechanisms underlying ischemia-augmented expression include: 1)...
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| Vydáno v: | J Gene Med |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6209320/ https://ncbi.nlm.nih.gov/pubmed/30101537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.3049 |
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