Structural and Biochemical Studies of Non-Native Agonists of the LasR Quorum Sensing Receptor Reveal an L3 Loop “Out” Conformation for LasR

Chemical strategies to block quorum sensing (QS) could provide a route to attenuate virulence in bacterial pathogens. Considerable research has focused on this approach in Pseudomonas aeruginosa, which uses the LuxR-type receptor LasR to regulate much of its QS network. Non-native ligands that antag...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: O’Reilly, Matthew C., Dong, Shihui, Rossi, Francis M., Karlen, Kaleigh M., Kumar, Rohan S., Nair, Satish K., Blackwell, Helen E.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209319/
https://ncbi.nlm.nih.gov/pubmed/30033130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2018.06.007
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