Heterogeneous distribution of trastuzumab in HER2-positive xenografts and metastases: role of the tumor microenvironment

Most HER2-positive metastatic breast cancer patients continue to relapse. Incomplete access to all target HER2-positive cells in metastases and tumor tissues is a potential mechanism of resistance to trastuzumab. The location of locally bound trastuzumab was evaluated in HER2-positive tissues in viv...

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Bibliografiska uppgifter
I publikationen:Clin Exp Metastasis
Huvudupphovsmän: Baker, Jennifer Hazel Elizabeth, Kyle, Alastair Hugh, Reinsberg, Stefan Alexander, Moosvi, Firas, Patrick, Haley Margaret, Cran, Jordan, Saatchi, Katayoun, Häfeli, Urs, Minchinton, Andrew Ivor
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Netherlands 2018
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6209006/
https://ncbi.nlm.nih.gov/pubmed/30196384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10585-018-9929-3
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