AT-47 PHASE I TRIAL OF INTRATHECAL TRASTUZUMAB IN HER2 POSITIVE LEPTOMENINGEAL METASTASES

INTRODUCTION: Trastuzimab is a humanized monoclonal antibody against Her2 whose limitation is central nervous system penetration that often leads to brain and leptomeningeal metastases (LM) in the setting to controlled systemic HER2 positive breast cancer. We performed a phase I clinical trial of in...

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Bibliografiske detaljer
Main Authors: Raizer, Jeffrey, Pentsova, Elena, Omuro, Antonio, Lin, Nancy, Nayak, Lakshmi, Quant, Eudocia, Kumthekar, Priya
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
Fag:
Adult Clinical Trials
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217826/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou237.46
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