Critical assessment of different methods for quantitative measurement of metallodrug-protein associations

Quantitative screening for potential drug–protein binding is an essential step in developing novel metal-based anticancer drugs. ICP–MS approaches are at the core of this task; however, many applications lack in the capability of large-scale high-throughput screenings and proper validation. In this...

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Veröffentlicht in:Anal Bioanal Chem
Hauptverfasser: Galvez, Luis, Theiner, Sarah, Grabarics, Márkó, Kowol, Christian R., Keppler, Bernhard K., Hann, Stephan, Koellensperger, Gunda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208971/
https://ncbi.nlm.nih.gov/pubmed/30155703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00216-018-1328-8
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