Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors

PURPOSE: Sphingosine kinase 1 (SK1) is a protooncogenic enzyme expressed in many human tumours and is associated with chemoresistance and poor prognosis. It is a potent therapy target and its inhibition chemosensitises solid tumours. Despite recent advances in SK1 inhibitors synthesis and validation...

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Vydáno v:Breast Cancer Res Treat
Hlavní autoři: Alshaker, Heba, Srivats, Shyam, Monteil, Danielle, Wang, Qi, Low, Caroline M. R., Pchejetski, Dmitri
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer US 2018
Témata:
Preclinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6208908/
https://ncbi.nlm.nih.gov/pubmed/30043096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-018-4900-1
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