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Field template-based design and biological evaluation of new sphingosine kinase 1 inhibitors
PURPOSE: Sphingosine kinase 1 (SK1) is a protooncogenic enzyme expressed in many human tumours and is associated with chemoresistance and poor prognosis. It is a potent therapy target and its inhibition chemosensitises solid tumours. Despite recent advances in SK1 inhibitors synthesis and validation...
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| Publicado en: | Breast Cancer Res Treat |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer US
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6208908/ https://ncbi.nlm.nih.gov/pubmed/30043096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-018-4900-1 |
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