NFκB Sensing IL-4 Secreting Mesenchymal Stem Cells Mitigate the Proinflammatory Response of Macrophages Exposed to Polyethylene Wear Particles

Total joint replacement (TJR) is a highly effective treatment for patients with end-stage arthritis. Pro-inflammatory macrophages (M1) mediate wear particle-associated inflammation and bone loss. Anti-inflammatory macrophages (M2) help resolve tissue damage and favor bone regeneration. Mesenchymal s...

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Vydáno v:J Biomed Mater Res A
Hlavní autoři: Lin, Tzuhua, Kohno, Yusuke, Huang, Jhih-Fong, Romero-Lopez, Monica, Pajarinen, Jukka, Maruyama, Masahiro, Nathan, Karthik, Yao, Zhenyu, Goodman, Stuart B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207939/
https://ncbi.nlm.nih.gov/pubmed/30084534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbm.a.36504
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