Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis

Although hedgehog (Hh) signaling pathway is inactive in adult healthy liver, it becomes activated during acute and chronic liver injury and, thus, modulates the reparative process and disease progression. We developed a novel mouse model with liver-specific knockout of Smoothened (Smo LKO), and anim...

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Veröffentlicht in:Am J Pathol
Hauptverfasser: Wang, Ying, Chen, Weina, Han, Chang, Zhang, Jinqiang, Song, Kyoungsub, Kwon, Hyunjoo, Dash, Srikanta, Yao, Lu, Wu, Tong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207910/
https://ncbi.nlm.nih.gov/pubmed/30366594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.07.018
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