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Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells

The physiological importance of the interactions between hyaluronic acid (HA) and its main membrane receptor, CD44, in pathological processes, e.g. cancer, is well recognized. However, these interactions are mainly studied in solution, whereas HA in the extracellular matrix (ECM) is partially immobi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Amorim, Sara, da Costa, Diana Soares, Freitas, Daniela, Reis, Celso A., Reis, Rui L., Pashkuleva, Iva, Pires, Ricardo A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207784/
https://ncbi.nlm.nih.gov/pubmed/30375477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34445-0
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