Molecular weight of surface immobilized hyaluronic acid influences CD44-mediated binding of gastric cancer cells

The physiological importance of the interactions between hyaluronic acid (HA) and its main membrane receptor, CD44, in pathological processes, e.g. cancer, is well recognized. However, these interactions are mainly studied in solution, whereas HA in the extracellular matrix (ECM) is partially immobi...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Amorim, Sara, da Costa, Diana Soares, Freitas, Daniela, Reis, Celso A., Reis, Rui L., Pashkuleva, Iva, Pires, Ricardo A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207784/
https://ncbi.nlm.nih.gov/pubmed/30375477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34445-0
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