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A novel in vitro allometric scaling methodology for aldehyde oxidase substrates to enable selection of appropriate species for traditional allometry
1. Failure to predict human pharmacokinetics of aldehyde oxidase (AO) substrates using traditional allometry has been attributed to species differences in AO metabolism. 2. To identify appropriate species for predicting human in vivo clearance by single species scaling (SSS) or multispecies allometr...
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| Publicado no: | Xenobiotica |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6207370/ https://ncbi.nlm.nih.gov/pubmed/28281401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1296208 |
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