A Critical Epithelial Survival Axis Regulated by MCL-1 Maintains Thymic Function in Mice

T cell differentiation is governed by interactions with thymic epithelial cells (TECs) and defects in this process undermine immune function and tolerance. To uncover new strategies to restore thymic function and adaptive immunity in immunodeficiency, we sought to determine the molecular mechanisms...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Jain, Reema, Sheridan, Julie M., Policheni, Antonia, Heinlein, Melanie, Gandolfo, Luke C., Dewson, Grant, Smyth, Gordon K, Sansom, Stephen N., Fu, Nai Yang, Visvader, Jane E., Holländer, Georg A., Strasser, Andreas, Gray, Daniel H.D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207344/
https://ncbi.nlm.nih.gov/pubmed/28972012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-03-771576
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