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Elevated Mcl-1 inhibits thymocyte apoptosis and alters thymic selection
T cells developing in the thymus undergo rigorous positive and negative selection to ensure that those exported to peripheral lymphoid organs bear T-cell receptors (TCRs) capable of reacting with foreign antigens but tolerant of self. At each checkpoint, whether a thymocyte survives or dies is deter...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3504710/ https://ncbi.nlm.nih.gov/pubmed/22743995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.84 |
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