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Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
Metformin is a first-line drug for the treatment of individuals with type 2 diabetes, yet its precise mechanism of action remains unclear. Metformin exerts its anti-hyperglycemic action primarily through lowering of hepatic glucose production (HGP). This suppression is thought to be mediated through...
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| Publicado no: | Nat Med |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6207338/ https://ncbi.nlm.nih.gov/pubmed/30150719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0159-7 |
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