pH-responsive hybrid nanoparticle with enhanced dissociation characteristic for siRNA delivery

INTRODUCTION: Specific polo-like kinase (PLK1) silencing with small interface RNA (siRNA) may be an effective approach for PLK1-overexpressed lung cancer. However, low siRNA concentration into cytoplasm of tumor tissue severely limits its application. MATERIALS AND METHODS: In this study, a novel tr...

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Publicado en:Int J Nanomedicine
Autores principales: Shi, Menghao, Zhao, Xiufeng, Zhang, Jiulong, Pan, Shuang, Yang, Chunrong, Wei, Ying, Hu, Haiyang, Qiao, Mingxi, Chen, Dawei, Zhao, Xiuli
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207255/
https://ncbi.nlm.nih.gov/pubmed/30498349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S180119
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