Anti-EphA10 antibody-conjugated pH-sensitive liposomes for specific intracellular delivery of siRNA

Therapeutic delivery of small interfering RNA (siRNA) is a major challenge that limits its potential clinical application. Here, a pH-sensitive cholesterol–Schiff base–polyethylene glycol (Chol–SIB–PEG)-modified cationic liposome–siRNA complex, conjugated with the recombinant humanized anti-EphA10 a...

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Detalhes bibliográficos
Publicado no:Int J Nanomedicine
Main Authors: Zang, Xinlong, Ding, Huaiwei, Zhao, Xiufeng, Li, Xiaowei, Du, Zhouqi, Hu, Haiyang, Qiao, Mingxi, Chen, Dawei, Deng, Yuihui, Zhao, Xiuli
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993279/
https://ncbi.nlm.nih.gov/pubmed/27574425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S107952
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