Mitochondria-targeted delivery of doxorubicin to enhance antitumor activity with HER-2 peptide-mediated multifunctional pH-sensitive DQAsomes

INTRODUCTION: Multidrug resistance (MDR) of breast cancer is the major challenge to successful chemotherapy while mitochondria-targeting therapy was a promising strategy to overcome MDR. MATERIALS AND METHODS: In this study, HER-2 peptide-PEG(2000)-Schiff base-cholesterol (HPSC) derivate was synthes...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Int J Nanomedicine
Auteurs principaux: Shi, Menghao, Zhang, Jiulong, Li, Xiaowei, Pan, Shuang, Li, Jie, Yang, Chunrong, Hu, Haiyang, Qiao, Mingxi, Chen, Dawei, Zhao, Xiuli
Format: Artigo
Langue:Inglês
Publié: Dove Medical Press 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054761/
https://ncbi.nlm.nih.gov/pubmed/30140154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S163858
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