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6mer seed toxicity in tumor suppressive microRNAs
Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most tox...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6206098/ https://ncbi.nlm.nih.gov/pubmed/30374110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06526-1 |
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