6mer seed toxicity in tumor suppressive microRNAs

Many small-interfering (si)RNAs are toxic to cancer cells through a 6mer seed sequence (positions 2–7 of the guide strand). Here we performed an siRNA screen with all 4096 6mer seeds revealing a preference for guanine in positions 1 and 2 and a high overall G or C content in the seed of the most tox...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Gao, Quan Q., Putzbach, William E., Murmann, Andrea E., Chen, Siquan, Sarshad, Aishe A., Peter, Johannes M., Bartom, Elizabeth T., Hafner, Markus, Peter, Marcus E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6206098/
https://ncbi.nlm.nih.gov/pubmed/30374110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06526-1
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk