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Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells
Trinucleotide repeat (TNR) expansions in the genome cause a number of degenerative diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin (HTT) gene responsible for Huntington's disease (HD). Pathology is caused by protein and RNA generated from the TNR regions including...
Guardado en:
| Publicado en: | EMBO Rep |
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| Autores principales: | , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5836092/ https://ncbi.nlm.nih.gov/pubmed/29440125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745336 |
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