Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

Trinucleotide repeat (TNR) expansions in the genome cause a number of degenerative diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin (HTT) gene responsible for Huntington's disease (HD). Pathology is caused by protein and RNA generated from the TNR regions including...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:EMBO Rep
Egile Nagusiak: Murmann, Andrea E, Gao, Quan Q, Putzbach, William E, Patel, Monal, Bartom, Elizabeth T, Law, Calvin Y, Bridgeman, Bryan, Chen, Siquan, McMahon, Kaylin M, Thaxton, C Shad, Peter, Marcus E
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836092/
https://ncbi.nlm.nih.gov/pubmed/29440125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745336
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