Small interfering RNAs based on huntingtin trinucleotide repeats are highly toxic to cancer cells

Trinucleotide repeat (TNR) expansions in the genome cause a number of degenerative diseases. A prominent TNR expansion involves the triplet CAG in the huntingtin (HTT) gene responsible for Huntington's disease (HD). Pathology is caused by protein and RNA generated from the TNR regions including...

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Vydáno v:EMBO Rep
Hlavní autoři: Murmann, Andrea E, Gao, Quan Q, Putzbach, William E, Patel, Monal, Bartom, Elizabeth T, Law, Calvin Y, Bridgeman, Bryan, Chen, Siquan, McMahon, Kaylin M, Thaxton, C Shad, Peter, Marcus E
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836092/
https://ncbi.nlm.nih.gov/pubmed/29440125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201745336
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