Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia

Mitochondria fulfill vital metabolic functions and act as crucial cellular signaling hubs, integrating their metabolic status into the cellular context. Here, we show that defective cardiolipin remodeling, upon loss of the cardiolipin acyl transferase tafazzin, decreases HIF-1α signaling in hypoxia....

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Chowdhury, Arpita, Aich, Abhishek, Jain, Gaurav, Wozny, Katharina, Lüchtenborg, Christian, Hartmann, Magnus, Bernhard, Olaf, Balleiniger, Martina, Alfar, Ezzaldin Ahmed, Zieseniss, Anke, Toischer, Karl, Guan, Kaomei, Rizzoli, Silvio O., Brügger, Britta, Fischer, Andrè, Katschinski, Dörthe M., Rehling, Peter, Dudek, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205837/
https://ncbi.nlm.nih.gov/pubmed/30332638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.057
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