Lysyl-tRNA synthetase–expressing colon spheroids induce M2 macrophage polarization to promote metastasis

Lysyl-tRNA synthetase (KRS) functions canonically in cytosolic translational processes. However, KRS is highly expressed in colon cancer, and localizes to distinct cellular compartments upon phosphorylations (i.e., the plasma membranes after T52 phosphorylation and the nucleus after S207 phosphoryla...

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Vydáno v:J Clin Invest
Hlavní autoři: Nam, Seo Hee, Kim, Doyeun, Lee, Doohyung, Lee, Hye-Mi, Song, Dae-Geun, Jung, Jae Woo, Kim, Ji Eon, Kim, Hye-Jin, Kwon, Nam Hoon, Jo, Eun-Kyeong, Kim, Sunghoon, Lee, Jung Weon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205414/
https://ncbi.nlm.nih.gov/pubmed/30188867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI99806
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