Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor (67LR) that is implicated in cancer metastasis; however, its potential as an antimetastatic therapeutic target has not been explore...

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Detalhes bibliográficos
Main Authors: Kim, Dae Gyu, Lee, Jin Young, Kwon, Nam Hoon, Fang, Pengfei, Zhang, Qian, Wang, Jing, Young, Nicolas L., Guo, Min, Cho, Hye Young, Mushtaq, AmeeqUl, Jeon, Young Ho, Choi, Jin Woo, Han, Jung Min, Kang, Ho Woong, Joo, Jae Eun, Hur, Youn, Kang, Wonyoung, Yang, Heekyoung, Nam, Do-Hyun, Lee, Mi-Sook, Lee, Jung Weon, Kim, Eun-Sook, Moon, Aree, Kim, Kibom, Kim, Doyeun, Kang, Eun Joo, Moon, Youngji, Rhee, Kyung Hee, Han, Byung Woo, Yang, Jee Sun, Han, Gyoonhee, Yang, Won Suk, Lee, Cheolju, Wang, Ming-Wei, Kim, Sunghoon
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021855/
https://ncbi.nlm.nih.gov/pubmed/24212136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1381
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