The anti-cancer effect of retinoic acid signaling in CRC occurs via decreased growth of ALDH+ colon cancer stem cells and increased differentiation of stem cells

BACKGROUND: Tumorigenesis is driven by stem cell (SC) overpopulation. Because ALDH is both a marker for SCs in many tissues and a key enzyme in retinoid acid (RA) signaling, we studied RA signaling in normal and malignant colonic SCs. HYPOTHESIS: RA signaling regulates growth and differentiation of...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Modarai, Shirin R., Gupta, Anindita, Opdenaker, Lynn M., Kowash, Ryan, Masters, Gabriel, Viswanathan, Vignesh, Zhang, Tao, Fields, Jeremy Z., Boman, Bruce M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205182/
https://ncbi.nlm.nih.gov/pubmed/30410666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26157
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